Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease.However, the mechanisms that lead to loss of barrier function remain poorly understood.Using D.melanogaster, we demonstrate that dietary restriction (DR) slows the age-related Shoe/Boot Covers decline in intestinal integrity by enhancing enterocyte cellul

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